G Protein Coupled Receptors GPCRs Market Report 2023 (Global Edition)

Global G Protein Coupled Receptors GPCRs Market Report 2023 talks about crucial market insights with the help of segments and sub-segments analysis. In this section, we reveal an in-depth analysis of the key factors influencing G Protein Coupled Receptors GPCRs Industry growth. G Protein Coupled Receptors GPCRs market has been segmented with the help of its Product, Application Assay Type, and others. G Protein Coupled Receptors GPCRs market analysis helps to understand key industry segments, and their global, regional, and country-level insights. Furthermore, this analysis also provides information pertaining to segments that are going to be most lucrative in the near future and their expected growth rate and future market opportunities. The report also provides detailed insights into factors responsible for the positive or negative growth of each industry segment.

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G Protein Coupled Receptors GPCRs Market,by type

Cell Lines

The Cell Lines segment Revenue will be USD 1,502.64 Million by 2028.

GPCR cell lines and cell-based assays are intended to identify GPCR signalling through second messenger activation, arrestin recruitment, and receptor internalization to simplify and speed up GPCR biology and drug development. In general, transduction of the host cell line and subsequent integration of the expression cassette into the host cell genome is required for the production of cell lines that stably express a transgene. 

As a result, the distribution of integration sites is random. Similarly, GPCR stable cell lines were used for monitoring ligand-induced GPCR internalization. The most significant feature of the GPCR-expressing cell lines is that it should be rapidly established (within 2–4 weeks), consistent expression, stable expression without a need of persistent use of selection agents, and sufficient expression of the receptors to monitor pharmacological responses.

Detection Kits

GPCR assay kits can be used to detect or evaluate G protein coupled receptors (GPCRs) activity on cell surfaces. GPCRs have a role in development, immunology, inflammation, and metabolism, among other biological processes. They're being explored as therapeutic targets since they're implicated in so many disease processes. GPCR assays can detect direct ligand binding or indirect GPCR-related activities including cAMP quantification and ß-Arrestin recruitment. GPCR assay kits can also be used to investigate the effects of agonists and antagonists on cell metabolism and signalling.

Cell Culture Reagents

The GPCRs reagent allows for the rapid extraction and stabilization of G coupled protein receptors (GPCRs) and other membrane-associated proteins from cultured mammalian cells or tissue while maintaining receptor integrity over the long term. The GPCR Reagent is easy to utilize. The material is collected, washed, and pelleted first. The reagent is subsequently used to extract the receptor, which is then centrifuged.

Ligands

The discovery of GPCR ligands has sparked a lot of interest in the chemical space of GPCRs. Several cheminformatics methodologies have been included in its drug discovery pipeline due to the continual rise in structural, ligand, and functional data of GPCRs. Several GPCRs, whose activities are mediated by ligand binding, are involved in various signalling pathways. The quantity of ligand-bound GPCR structures reveals the complexities of ligand-receptor interactions, prompting a transition away from traditional HTS methodologies toward less expensive and more efficient SBDD approaches for the design and discovery of powerful ligands with better pharmacological profiles.

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G Protein Coupled Receptors GPCRs Market,by Application

Cancer Research

The Cancer Research segment Revenue in G Protein Coupled Receptors GPCRs will be USD 1,064.47 Million by 2028.

G protein coupled receptors (GPCRs) are a broad family of cell surface signalling receptors that have been linked to a variety of cancers. GPCRs are thought to regulate numerous facets of cancer progression, including tumor growth, invasion, migration, survival, and metastasis, according to several studies. The lack of usage of GPCR-targeted medicines as cancer treatments is likely due to a lack of understanding about GPCR expression in cancer cells. As a result, scientists conducted GPCRomic experiments in a variety of cancer cells to determine the expression of endoGPCRs (which respond to endogenous substances such as hormones, neurotransmitters, and metabolites). These discoveries can help researchers get a better understanding of the biological activity triggered by GPCRs in tumor cells and lead to the development of new pharmacological treatments for cancer patients.

CNS Research

GPCRs are the most significant targets in modern pharmacology due to the many roles they mediate, particularly in the brain and peripheral nervous system, as well as their functional and stereochemical features. Many antipsychotic medications now on the market also operate as antagonists or agonists of certain GPCRs. As a result, GPCR-based medication research is becoming increasingly popular as a way to control neurodegeneration and related cognitive impairments by modulating canonical and noncanonical signals. The number of medications targeting GPCRs is projected to rise as novel roles for GPCRs are identified, particularly for the 100 orphan GPCRs for which no endogenous ligand or well-defined function is presently known. As a result, the importance of different kinds of GPCRs in neurodegeneration and the advancement of age-related diseases is in the focus.

Metabolic Research

GPCRs are involved in a variety of pathophysiological circumstances and regulate a variety of metabolic processes, including glucose homeostasis and insulin secretion, hunger, calcium-sensing, heart rate, and blood pressure, and sleep, to name a few. Many pre-clinical and clinical investigations have been carried out to better understand the role of GPCRs in diverse metabolic tissues, paving the way for the development of GPCR-based medicines to treat metabolic diseases. Importantly, different metabolite GPCRs act as effective pro- and anti-inflammatory regulators of key immune cells, suggesting that signalling metabolites may play a role in the low-grade inflammation linked to insulin resistance and obesity. In addition to their bioenergetic intracellular role, certain classical metabolites, like hormones and neurotransmitters, operate as extracellular signalling molecules by activating cell-surface G protein coupled receptors (GPCRs).

Cardiovascular Research

GPCRs play a critical role in the control of heart function in both health and illness and are consequently one of the most commonly targeted surface receptors by pharmaceuticals. The pathophysiology of heart disease is determined by GPCR signalling pathways and GRKs in the heart. Increased expression and activity of GRK2 and GRK5 have been linked to the loss of contractile reserve in stressed and failing hearts, suggesting that inhibiting hyperactive GRKs might be the next step in treating heart failure. Several GPCR antagonists, such as -adrenergic receptors (ARs) and Ang II (angiotensin II) receptors, are now standard of care for a variety of cardiovascular diseases, including hypertension, coronary artery disease, and heart failure. Treatment strategies that focus on the complex and interconnected signalling pathways of these GPCRs are crucial for understanding and treating cardiac disease.

Respiratory Research

G protein coupled receptors (GPCRs) regulate a variety of tasks in airway smooth muscle (ASM), including contraction, growth, and "synthetic" actions that organize airway inflammation and promote airway architectural remodelling. This is especially true for pharmaceuticals used to treat airway illnesses like asthma; it is widely known that GPCRs on airway smooth muscle (ASM) are the direct targets of the bulk of anti-asthma medications. Until recently, the majority of research on GPCR expression, function, and regulation in ASM has been on receptors that may dynamically regulate ASM contractile state and, as a result, airway resistance.

Inflammation Research

The cardinal indications of inflammation are rubor (redness), calor (heat), dolor (pain), tumor (swelling), and function laesa (loss of function). These symptoms are a result of tissue reaction to inflammatory substances that are either external (e.g., bacterial endotoxin) or internal (e.g., TNF). Because of their widespread distribution and numerous activities, GPCRs have a direct role in these clinical symptoms. Inflammation is mediated by G protein coupled receptors (GPCRs). GPCRs for traditional chemoattractants and chemokines are abundant in inflammatory cells such as polymorphonuclear leukocytes (PMN), monocytes, and macrophages. Many GPCRs found in inflammatory cells also play a role in transcription factor activation, which results in the production and release of inflammatory factors and, in some circumstances, anti-inflammatory chemicals. Understanding GPCR signaling pathways in inflammatory cells would likely assist translational research and the development of better anti-inflammatory medicines.

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G Protein Coupled Receptors GPCRs Assay Type Segment Analysis

cAMP Functional Assays

The cAMP Functional Assays segment Revenue in G Protein Coupled Receptors GPCRs will be USD 1,286.30 Million by 2028.

The activation of G protein coupled receptors (GPCRs) regulates cyclic adenosine monophosphate (cAMP), a common second messenger that mediates a variety of biological reactions. In molecular pharmacological investigations of GPCRs, measuring intracellular cAMP levels remains an essential approach. cAMP biosensors based on fluorescence resonance energy transfer (FRET) have recently been utilized to monitor real-time GPCR-mediated changes in intracellular cAMP levels using FRET microscopy.

Calcium Functional Assays

Calcium functional assays are widely available as calcium flux assays. When it comes to defining G protein coupled receptors (GPCRs) and screening GPCR agonists and antagonists, calcium flux assays are the favored approach. These assays are highly sensitive, easier in the estimation of calcium flux, and user configurability. Intracellular calcium assays that employ a fluorescent calcium-binding dye (such as Fluo-3, Fluo-4, or Fura-2) to measure the activity of Gq-coupled GPCRs have been used in drug screening campaigns to test the activity of Gq-coupled GPCRs.

Β-Arrestin Functional Assays

β-Arrestin assays provide a generic assay platform for drug discovery on G protein coupled receptors (GPCRs). The data indicate that the β-arrestin enzyme fragment complementation cell line can be used for agonistic screening of GPCRs and the identification of “biased ligands”. Likewise, β-Arrestin not only inhibits G-protein signalling, but it can also connect GPCRs to members of the Src and mitogen-activated protein kinase (MAPK) families, including extracellular-signal-regulated kinases 1 and 2.

Radioligand Binding and GTPγS Functional

Radioligand binding assays are critical for drug structure-activity investigations and basic GPCR research because they give sensitive and quantitative information regarding guanine nucleotide protein G protein-coupled receptor (GPCR) expression and affinity for a wide range of ligands. Although GTPS binding tests employ membrane preparations in the same manner as radioligand binding assays do, these are functional assays that may be used to distinguish agonist, antagonist, and inverse agonist actions. GTPγS binding assays directly detect G protein guanine nucleotide exchange, an early event after GPCR activation that is neither amplified nor regulated by other physiological processes.

Internalization Assays

Internalization of GPCRs is required to protect cells from excessive receptor stimulation or periods of inactivity. If a ligand, a protein mutation, or abnormal signalling prevents GPCR internalization, undesired consequences can arise, leading to drug tolerance, unpleasant side effects, and illness. Additionally, GPCR internalization assays are cell-based functional assays for measuring GPCR measured directly and quantitatively using this non-imaging, non-antibody-based chemiluminescent technique. Internalization plays a role in the variety of GPCR-dependent signalling, and its dynamics and quantification in live cells have attracted researchers' attention. This method uses diffusion-enhanced resonance energy transfer (DERET) between cell surface GPCRs tagged with a luminous terbium cryptate donor and a fluorescein acceptor present in the culture medium.

Trafficking Assays

G protein-coupled receptor (GPCR) trafficking is increasingly recognized as playing a critical role in receptor-mediated signalling and regulation. Live imaging of GPCR trafficking in cultured cells and tissues has been used in several recent investigations. Also, a variety of markers have been developed to assist researchers in distinguishing between distinct types of internal membrane compartments that are crucial to GPCR trafficking.Imaging of receptor localization and redistribution in living specimens is a prominent area of fast progress in the study of GPCR trafficking. Such methods can provide crucial information on regulatory processes that occur in real-time in response to physiological or pharmacological inputs.

• cAMP Functional Assays
• Calcium Functional Assays
• ?-Arrestin Functional Assays
• Radioligand Binding and GTP?S Functional
• Internalization Assays
• Trafficking Assays
• Other

G Protein Coupled Receptors GPCRs Market Regional Analysis

Region and country analysis section of G Protein Coupled Receptors GPCRs Industry Analysis has been segmented into 5 major region such as North America, Europe, Asia Pacific, Middle East & Africa ,and Latin America (along with respective major contributing countries) and provides the revenue share, current trends.

The base years considered for all the estimations by analyzing trends and growth rate will help you gain an in-depth understanding of the conclusions provided in this report. This report also includes figures, graphs, pie charts, tables and bar graphs that explain the data analysis based on current trends at the country level as well as key regions. This research report also focuses on assessing factors such as profit, product price, capacity, production, supply demand market growth rate along with others to create a clear picture on the future prospects of G Protein Coupled Receptors GPCRs market.

Region-wise, the market is analyzed across: (In case you wish to acquire a specific region or any country data then please contact us)

• North America (United States, Canada, Mexico)
• Europe (United Kingdom, France, Germany, Italy, Russia, Spain, Sweden, Denmark, Netherlands, Switzerland, Belgium)
• Asia-Pacific (China, Japan, Korea, India, Australia, Philippines, Singapore, Malaysia, Thailand, Indonesia, Rest of APAC)
• South America (Brazil, Argentina, Colombia, Peru, Chile, Rest of South America)
• Middle East and Africa (Saudi Arabia, Turkey, Nigeria, UAE, Egypt, South Africa, GCC Countries, Rest of MEA)

The above graph is for illustrative purposes only. To learn more about geographical trends request the free sample pages. Contact US!

The base years considered for all the estimations by analyzing trends and growth rate will help you gain an in-depth understanding of the conclusions provided in this report. This report also includes figures, graphs, pie charts, tables and bar graphs that explain the data analysis based on current trends at the country level as well as key regions. This research report also focuses on assessing factors such as profit, product price, capacity, production, supply demand market growth rate along with others to create a clear picture on the future prospects of this market.

Company Profile:

Thermo Fisher Scientific Inc.

Thermo Fischer Scientific Inc is engaged in the manufacturing and distribution of several products in the market. The brands offered by the portfolio include Thermo scientific, applied biosystem, Invitrogen, fisher scientific, unity labs services, and Patheon. The company develops HLA typing solutions in the market, which assist in the transplantation of organs. Additionally, the services offered by the company are custom service, enterprises, instrument service, and others.

RECENT NEWS

April 2021    

Thermo Fisher Scientific Inc. acquired PPD Company

The company acquired PPPD, a clinical research organization that provide quality service in the market, this acquisition has accelerated innovation and increase drug development productivity, optimization in service ensuring customer satisfaction.

October 2020

Thermo Fischer Scientific Inc. engaged in partnership with Terasaki Innovation Center 

Thermo Fischer Scientific Inc has engaged in partnership with Terasaki Innovation Center for facilitating development of new pathways and products to diagnose and manage transplantation of patients.

Eurofins DiscoverX Products

Eurofins DiscoverX Products is a manufacturer of assays, stable cell lines, membrane preps, enzymes and others. The products of the company have several applications such as drug discovery & development, potency & QC lot release, detect neutralizing abs, cell banks for bioassays, targeted protein degradation and others. The company offers broad range of product portfolio including, 
     Cells & Cell Lines
     Assay Ready Kits
     Bioassay Kits
     eXpress Kits
     Frozen Cells
     Membrane Preps
     Proteins & Kinases
     Cell Culture Reagents
     Detection Reagents
     Biochemical Assays
     Control Ligands & Inhibitors

Top Companies Market Share in G Protein Coupled Receptors GPCRs Industry: (In no particular order of Rank)

• romega Corporation
• PerkinElmer Inc.
• Thermo Fisher Scientific
• Enzo Biochem Inc. (Enzo Life Sciences Inc.)
• Eurofins DiscoverX Products
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