Global G Protein Coupled Receptors GPCRs
Market Report
2025
As per Cognitive Market Research's latest published report, the Global G Protein Coupled Receptors GPCRs market size will be $4,035.97 Million by 2028. G Protein Coupled Receptors GPCRs Industry's Compound Annual Growth Rate will be 6.36% from 2023 to 2030.
The base year for the calculation is 2024. The historical will be 2021 to 2024. The year 2025 will be estimated one while the forecasted data will be from year 2025 to 2033. When we deliver the report that time we updated report data till the purchase date.
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As per Cognitive Market Research's latest published report, the Global G Protein Coupled Receptors GPCRs market size will be $4,035.97 Million by 2028. G Protein Coupled Receptors GPCRs Industry's Compound Annual Growth Rate will be 6.36% from 2023 to 2030.
The North America G Protein Coupled Receptors GPCRs market size will be USD 1,316.33 Million by 2028.
2021 | 2025 | 2033 | CAGR | |
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Global G Protein Coupled Receptors GPCRs Market Sales Revenue | 121212 | 121212 | 121212 | 6.36% |
Base Year | 2024 |
Historical Data Time Period | 2021-2024 |
Forecast Period | 2025-2033 |
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G Protein Coupled Receptors GPCRs Market is Segmented as below. Particular segment of your interest can be provided without any additional cost. Download the Sample Pages!
GPCRs are the biggest protein family encoded by the human genome. The G-protein coupled receptor (GPCR), also known as the seven-transmembrane receptor or heptahelical receptor, is a protein found in the cell membrane that binds external chemicals and transmits signals to an intracellular component known as a G protein (guanine nucleotide-binding protein). Their endogenous ligands range from photons, amines, carbohydrates, lipids, peptides, and proteins to smells, hormones, neurotransmitters, and chemokines.
GPCRs can be found in the cell membranes of mammals, plants, microbes, and invertebrates, among other organisms. It may respond to a wide range of chemicals, including light, hormones, amines, neurotransmitters, and lipids, and there are over 1,000 distinct varieties encoded by the human genome alone. GPCRs include beta-adrenergic receptors, which bind adrenaline, prostaglandin E2 receptors, which bind inflammatory compounds known as prostaglandins, and rhodopsin, which includes a photoreactive molecule known as retinal, which response to light signals received by rod cells in the eye.
GPCRs are involved in a wide range of processes in the human body, and a better knowledge of these receptors has had a significant impact on modern medicine. When a signaling molecule binds to a GPCR, it activates G proteins, which causes the creation of any number of second messengers. As a result, it has played significant a role in regulating a wide range of body activities, from sensation to growth to hormone responses. Experts believe that GPCRs are involved in the action of one-third to half of all marketed medications. GPCRs have been linked to a wide range of disorders, including type 2 diabetes mellitus (T2DM), obesity, depression, cancer, Alzheimer's disease, and many more.GPCRs are available in cell lines, kits, ligands, reagents and also can be found as assays. Traditional cell-based GPCR assays rely on functional responses generated by heterotrimeric guanine nucleotide-binding proteins (G-proteins) upon receptor activation, such as stimulation or inhibition of second-messenger synthesis or gene transcription. To find novel low molecular weight modulators of GPCRs, numerous pharmaceutical companies continue to conduct high-throughput screening (HTS) on huge chemical compound libraries.
Chronic diseases and conditions are on the rise worldwide. Major reason for this is growing middle class population and urbanization which results in shifting towards more sedentary lifestyle. It has increased rate of obesity and diseases such as diabetes, and cardiac disorders upward. Dietary choices, such as exposure and access to ultra-processed food has dramatically increased the prevalence of cardiac problems in young population. It has been seen that heart attacks occurring in young men who are only 25 or 35. This can be attributed to the shift in people’s day-to-day lifestyle. Further, the WHO has estimated that chronic disease prevalence will rise by 57% in year 2020.
Cancer cases has been increased by 28% between 2006 and 2016. Cancer prevalence means the number of people in the population who have had a diagnosis of cancer. The incidence of cancer increase has multiple etiologies. Cancer is the second leading cause of death globally, and is responsible for about 10 million deaths per year.
It is estimated that about 1 in 6 deaths is due to cancer. Major risk factors for cancer are tobacco use, alcohol use, and change in lifestyle, unhealthy diet, physical inactivity and air pollution. All these factors have increased the prevalence of cancer among world's population. Moreover, some chronic diseases are risk factors for cancer especially in low- and middle-income countries. Approximately 13% of cancers diagnosed in 2018 globally were attributed to carcinogenic infections, including Helicobacter pylori, human papillomavirus (HPV), hepatitis B virus, hepatitis C virus, and Epstein-Barr virus.
Additional factors majorly responsible for the increasing number of cancer patients all around the globe include combination of environmental and lifestyle factors, and changes in screening and diagnosis. Further, rates of obesity in adolescents and young adults have increased considerably in recent decades. This increases the chances of growth of cancerous cell.
Implementation of GPCR assays in cancer treatment boost its demand in various drugs. Hence, increasing prevalence of chronic diseases, especially cancer enhances the growth of G Protein Coupled Receptors GPCRs market globally.
Restraints for G Protein Coupled Receptors GPCRs Market
Opportunities for G Protein Coupled Receptors GPCRs Market
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Thermo Fischer Scientific Inc is engaged in the manufacturing and distribution of several products in the market. The brands offered by the portfolio include Thermo scientific, applied biosystem, Invitrogen, fisher scientific, unity labs services, and Patheon. The company develops HLA typing solutions in the market, which assist in the transplantation of organs. Additionally, the services offered by the company are custom service, enterprises, instrument service, and others.
April 2021
The company acquired PPPD, a clinical research organization that provide quality service in the market, this acquisition has accelerated innovation and increase drug development productivity, optimization in service ensuring customer satisfaction.
October 2020
Thermo Fischer Scientific Inc has engaged in partnership with Terasaki Innovation Center for facilitating development of new pathways and products to diagnose and manage transplantation of patients.
Eurofins DiscoverX Products is a manufacturer of assays, stable cell lines, membrane preps, enzymes and others. The products of the company have several applications such as drug discovery & development, potency & QC lot release, detect neutralizing abs, cell banks for bioassays, targeted protein degradation and others. The company offers broad range of product portfolio including,
Cells & Cell Lines
Assay Ready Kits
Bioassay Kits
eXpress Kits
Frozen Cells
Membrane Preps
Proteins & Kinases
Cell Culture Reagents
Detection Reagents
Biochemical Assays
Control Ligands & Inhibitors
Top Companies Market Share in G Protein Coupled Receptors GPCRs Industry: (In no particular order of Rank)
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Region and country analysis section of G Protein Coupled Receptors GPCRs Industry Analysis has been segmented into 5 major region such as North America, Europe, Asia Pacific, Middle East & Africa ,and Latin America (along with respective major contributing countries) and provides the revenue share, current trends.
The base years considered for all the estimations by analyzing trends and growth rate will help you gain an in-depth understanding of the conclusions provided in this report. This report also includes figures, graphs, pie charts, tables and bar graphs that explain the data analysis based on current trends at the country level as well as key regions. This research report also focuses on assessing factors such as profit, product price, capacity, production, supply demand market growth rate along with others to create a clear picture on the future prospects of G Protein Coupled Receptors GPCRs market.
The current report Scope analyzes G Protein Coupled Receptors GPCRs Market on 5 major region Split (In case you wish to acquire a specific region edition (more granular data) or any country Edition data then please write us on info@cognitivemarketresearch.com
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Global G Protein Coupled Receptors GPCRs Market Report 2025 Edition talks about crucial market insights with the help of segments and sub-segments analysis. In this section, we reveal an in-depth analysis of the key factors influencing G Protein Coupled Receptors GPCRs Industry growth. G Protein Coupled Receptors GPCRs market has been segmented with the help of its Product, Application Assay Type, and others. G Protein Coupled Receptors GPCRs market analysis helps to understand key industry segments, and their global, regional, and country-level insights. Furthermore, this analysis also provides information pertaining to segments that are going to be most lucrative in the near future and their expected growth rate and future market opportunities. The report also provides detailed insights into factors responsible for the positive or negative growth of each industry segment.
The Cell Lines segment Revenue will be USD 1,502.64 Million by 2028.
GPCR cell lines and cell-based assays are intended to identify GPCR signalling through second messenger activation, arrestin recruitment, and receptor internalization to simplify and speed up GPCR biology and drug development. In general, transduction of the host cell line and subsequent integration of the expression cassette into the host cell genome is required for the production of cell lines that stably express a transgene.
As a result, the distribution of integration sites is random. Similarly, GPCR stable cell lines were used for monitoring ligand-induced GPCR internalization. The most significant feature of the GPCR-expressing cell lines is that it should be rapidly established (within 2–4 weeks), consistent expression, stable expression without a need of persistent use of selection agents, and sufficient expression of the receptors to monitor pharmacological responses.
GPCR assay kits can be used to detect or evaluate G protein coupled receptors (GPCRs) activity on cell surfaces. GPCRs have a role in development, immunology, inflammation, and metabolism, among other biological processes. They're being explored as therapeutic targets since they're implicated in so many disease processes. GPCR assays can detect direct ligand binding or indirect GPCR-related activities including cAMP quantification and ß-Arrestin recruitment. GPCR assay kits can also be used to investigate the effects of agonists and antagonists on cell metabolism and signalling.
The GPCRs reagent allows for the rapid extraction and stabilization of G coupled protein receptors (GPCRs) and other membrane-associated proteins from cultured mammalian cells or tissue while maintaining receptor integrity over the long term. The GPCR Reagent is easy to utilize. The material is collected, washed, and pelleted first. The reagent is subsequently used to extract the receptor, which is then centrifuged.
The discovery of GPCR ligands has sparked a lot of interest in the chemical space of GPCRs. Several cheminformatics methodologies have been included in its drug discovery pipeline due to the continual rise in structural, ligand, and functional data of GPCRs. Several GPCRs, whose activities are mediated by ligand binding, are involved in various signalling pathways. The quantity of ligand-bound GPCR structures reveals the complexities of ligand-receptor interactions, prompting a transition away from traditional HTS methodologies toward less expensive and more efficient SBDD approaches for the design and discovery of powerful ligands with better pharmacological profiles.
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The Cancer Research segment Revenue in G Protein Coupled Receptors GPCRs will be USD 1,064.47 Million by 2028.
G protein coupled receptors (GPCRs) are a broad family of cell surface signalling receptors that have been linked to a variety of cancers. GPCRs are thought to regulate numerous facets of cancer progression, including tumor growth, invasion, migration, survival, and metastasis, according to several studies. The lack of usage of GPCR-targeted medicines as cancer treatments is likely due to a lack of understanding about GPCR expression in cancer cells. As a result, scientists conducted GPCRomic experiments in a variety of cancer cells to determine the expression of endoGPCRs (which respond to endogenous substances such as hormones, neurotransmitters, and metabolites). These discoveries can help researchers get a better understanding of the biological activity triggered by GPCRs in tumor cells and lead to the development of new pharmacological treatments for cancer patients.
GPCRs are the most significant targets in modern pharmacology due to the many roles they mediate, particularly in the brain and peripheral nervous system, as well as their functional and stereochemical features. Many antipsychotic medications now on the market also operate as antagonists or agonists of certain GPCRs. As a result, GPCR-based medication research is becoming increasingly popular as a way to control neurodegeneration and related cognitive impairments by modulating canonical and noncanonical signals. The number of medications targeting GPCRs is projected to rise as novel roles for GPCRs are identified, particularly for the 100 orphan GPCRs for which no endogenous ligand or well-defined function is presently known. As a result, the importance of different kinds of GPCRs in neurodegeneration and the advancement of age-related diseases is in the focus.
GPCRs are involved in a variety of pathophysiological circumstances and regulate a variety of metabolic processes, including glucose homeostasis and insulin secretion, hunger, calcium-sensing, heart rate, and blood pressure, and sleep, to name a few. Many pre-clinical and clinical investigations have been carried out to better understand the role of GPCRs in diverse metabolic tissues, paving the way for the development of GPCR-based medicines to treat metabolic diseases. Importantly, different metabolite GPCRs act as effective pro- and anti-inflammatory regulators of key immune cells, suggesting that signalling metabolites may play a role in the low-grade inflammation linked to insulin resistance and obesity. In addition to their bioenergetic intracellular role, certain classical metabolites, like hormones and neurotransmitters, operate as extracellular signalling molecules by activating cell-surface G protein coupled receptors (GPCRs).
GPCRs play a critical role in the control of heart function in both health and illness and are consequently one of the most commonly targeted surface receptors by pharmaceuticals. The pathophysiology of heart disease is determined by GPCR signalling pathways and GRKs in the heart. Increased expression and activity of GRK2 and GRK5 have been linked to the loss of contractile reserve in stressed and failing hearts, suggesting that inhibiting hyperactive GRKs might be the next step in treating heart failure. Several GPCR antagonists, such as -adrenergic receptors (ARs) and Ang II (angiotensin II) receptors, are now standard of care for a variety of cardiovascular diseases, including hypertension, coronary artery disease, and heart failure. Treatment strategies that focus on the complex and interconnected signalling pathways of these GPCRs are crucial for understanding and treating cardiac disease.
G protein coupled receptors (GPCRs) regulate a variety of tasks in airway smooth muscle (ASM), including contraction, growth, and "synthetic" actions that organize airway inflammation and promote airway architectural remodelling. This is especially true for pharmaceuticals used to treat airway illnesses like asthma; it is widely known that GPCRs on airway smooth muscle (ASM) are the direct targets of the bulk of anti-asthma medications. Until recently, the majority of research on GPCR expression, function, and regulation in ASM has been on receptors that may dynamically regulate ASM contractile state and, as a result, airway resistance.
The cardinal indications of inflammation are rubor (redness), calor (heat), dolor (pain), tumor (swelling), and function laesa (loss of function). These symptoms are a result of tissue reaction to inflammatory substances that are either external (e.g., bacterial endotoxin) or internal (e.g., TNF). Because of their widespread distribution and numerous activities, GPCRs have a direct role in these clinical symptoms. Inflammation is mediated by G protein coupled receptors (GPCRs). GPCRs for traditional chemoattractants and chemokines are abundant in inflammatory cells such as polymorphonuclear leukocytes (PMN), monocytes, and macrophages. Many GPCRs found in inflammatory cells also play a role in transcription factor activation, which results in the production and release of inflammatory factors and, in some circumstances, anti-inflammatory chemicals. Understanding GPCR signaling pathways in inflammatory cells would likely assist translational research and the development of better anti-inflammatory medicines.
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The cAMP Functional Assays segment Revenue in G Protein Coupled Receptors GPCRs will be USD 1,286.30 Million by 2028.
The activation of G protein coupled receptors (GPCRs) regulates cyclic adenosine monophosphate (cAMP), a common second messenger that mediates a variety of biological reactions. In molecular pharmacological investigations of GPCRs, measuring intracellular cAMP levels remains an essential approach. cAMP biosensors based on fluorescence resonance energy transfer (FRET) have recently been utilized to monitor real-time GPCR-mediated changes in intracellular cAMP levels using FRET microscopy.
Calcium functional assays are widely available as calcium flux assays. When it comes to defining G protein coupled receptors (GPCRs) and screening GPCR agonists and antagonists, calcium flux assays are the favored approach. These assays are highly sensitive, easier in the estimation of calcium flux, and user configurability. Intracellular calcium assays that employ a fluorescent calcium-binding dye (such as Fluo-3, Fluo-4, or Fura-2) to measure the activity of Gq-coupled GPCRs have been used in drug screening campaigns to test the activity of Gq-coupled GPCRs.
β-Arrestin assays provide a generic assay platform for drug discovery on G protein coupled receptors (GPCRs). The data indicate that the β-arrestin enzyme fragment complementation cell line can be used for agonistic screening of GPCRs and the identification of “biased ligands”. Likewise, β-Arrestin not only inhibits G-protein signalling, but it can also connect GPCRs to members of the Src and mitogen-activated protein kinase (MAPK) families, including extracellular-signal-regulated kinases 1 and 2.
Radioligand binding assays are critical for drug structure-activity investigations and basic GPCR research because they give sensitive and quantitative information regarding guanine nucleotide protein G protein-coupled receptor (GPCR) expression and affinity for a wide range of ligands. Although GTPS binding tests employ membrane preparations in the same manner as radioligand binding assays do, these are functional assays that may be used to distinguish agonist, antagonist, and inverse agonist actions. GTPγS binding assays directly detect G protein guanine nucleotide exchange, an early event after GPCR activation that is neither amplified nor regulated by other physiological processes.
Internalization of GPCRs is required to protect cells from excessive receptor stimulation or periods of inactivity. If a ligand, a protein mutation, or abnormal signalling prevents GPCR internalization, undesired consequences can arise, leading to drug tolerance, unpleasant side effects, and illness. Additionally, GPCR internalization assays are cell-based functional assays for measuring GPCR measured directly and quantitatively using this non-imaging, non-antibody-based chemiluminescent technique. Internalization plays a role in the variety of GPCR-dependent signalling, and its dynamics and quantification in live cells have attracted researchers' attention. This method uses diffusion-enhanced resonance energy transfer (DERET) between cell surface GPCRs tagged with a luminous terbium cryptate donor and a fluorescein acceptor present in the culture medium.
G protein-coupled receptor (GPCR) trafficking is increasingly recognized as playing a critical role in receptor-mediated signalling and regulation. Live imaging of GPCR trafficking in cultured cells and tissues has been used in several recent investigations. Also, a variety of markers have been developed to assist researchers in distinguishing between distinct types of internal membrane compartments that are crucial to GPCR trafficking.Imaging of receptor localization and redistribution in living specimens is a prominent area of fast progress in the study of GPCR trafficking. Such methods can provide crucial information on regulatory processes that occur in real-time in response to physiological or pharmacological inputs.
Research Associate at Cognitive Market Research
Anushka Gore is a seasoned market researcher specializing in the dynamic landscape of the Pharmaceutical industry. With a keen analytical mind and a deep passion for healthcare advancements, she has dedicated herself unraveling the intricate market trends and consumer behaviors that shape the future of medical technologies and services.
Anushka Gore is a seasoned market researcher specializing in the dynamic landscape of the medical devices & consumables industry. She has dedicated herself unraveling the intricate market trends and consumer behaviors that shape the future of medical technologies and services. Her expertise in Market Research and business intelligence has equipped her with the skills necessary to analyze complex information and provide strategic recommendations.
In her current role, Anushka is a highly motivated and detail-oriented research analyst with a passion for uncovering valuable insights from data. She thrives in dynamic environments where her analytical abilities and research expertise can contribute to informed decision-making for businesses. Her collaborative approach facilitated effective communication of insights, fostering a data-driven culture within the organization.Anushka remains an invaluable asset in the dynamic landscape of market research.
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Product | Cell Lines, Detection Kits, Cell Culture Reagents, Ligands |
Application | Cancer Research, CNS Research, Metabolic Research, Cardiovascular Research, Respiratory Research, Inflammation Research, Other |
Assay Type | cAMP Functional Assays, Calcium Functional Assays, ?-Arrestin Functional Assays, Radioligand Binding and GTP?S Functional, Internalization Assays, Trafficking Assays, Other |
List of Competitors | romega Corporation, PerkinElmer Inc., Thermo Fisher Scientific, Enzo Biochem Inc. (Enzo Life Sciences Inc.), Eurofins DiscoverX Products |
This chapter will help you gain GLOBAL Market Analysis of G Protein Coupled Receptors GPCRs. Further deep in this chapter, you will be able to review Global G Protein Coupled Receptors GPCRs Market Split by various segments and Geographical Split.
Chapter 1 Global Market Analysis
Global Market has been segmented on the basis 5 major regions such as North America, Europe, Asia-Pacific, Middle East & Africa, and Latin America.
You can purchase only the Executive Summary of Global Market (2019 vs 2024 vs 2031)
Global Market Dynamics, Trends, Drivers, Restraints, Opportunities, Only Pointers will be deliverable
This chapter will help you gain North America Market Analysis of G Protein Coupled Receptors GPCRs. Further deep in this chapter, you will be able to review North America G Protein Coupled Receptors GPCRs Market Split by various segments and Country Split.
Chapter 2 North America Market Analysis
This chapter will help you gain Europe Market Analysis of G Protein Coupled Receptors GPCRs. Further deep in this chapter, you will be able to review Europe G Protein Coupled Receptors GPCRs Market Split by various segments and Country Split.
Chapter 3 Europe Market Analysis
This chapter will help you gain Asia Pacific Market Analysis of G Protein Coupled Receptors GPCRs. Further deep in this chapter, you will be able to review Asia Pacific G Protein Coupled Receptors GPCRs Market Split by various segments and Country Split.
Chapter 4 Asia Pacific Market Analysis
This chapter will help you gain South America Market Analysis of G Protein Coupled Receptors GPCRs. Further deep in this chapter, you will be able to review South America G Protein Coupled Receptors GPCRs Market Split by various segments and Country Split.
Chapter 5 South America Market Analysis
This chapter will help you gain Middle East Market Analysis of G Protein Coupled Receptors GPCRs. Further deep in this chapter, you will be able to review Middle East G Protein Coupled Receptors GPCRs Market Split by various segments and Country Split.
Chapter 6 Middle East Market Analysis
This chapter will help you gain Middle East Market Analysis of G Protein Coupled Receptors GPCRs. Further deep in this chapter, you will be able to review Middle East G Protein Coupled Receptors GPCRs Market Split by various segments and Country Split.
Chapter 7 Africa Market Analysis
This chapter provides an in-depth analysis of the market share among key competitors of G Protein Coupled Receptors GPCRs. The analysis highlights each competitor's position in the market, growth trends, and financial performance, offering insights into competitive dynamics, and emerging players.
Chapter 8 Competitor Analysis (Subject to Data Availability (Private Players))
(Subject to Data Availability (Private Players))
Data Subject to Availability as we consider Top competitors and their market share will be delivered.
Data Subject to Availability as we consider Top competitors and their market share will be delivered.
Data Subject to Availability as we consider Top competitors and their market share will be delivered.
Data Subject to Availability as we consider Top competitors and their market share will be delivered.
Data Subject to Availability as we consider Top competitors and their market share will be delivered.
This chapter would comprehensively cover market drivers, trends, restraints, opportunities, and various in-depth analyses like industrial chain, PESTEL, Porter’s Five Forces, and ESG, among others. It would also include product life cycle, technological advancements, and patent insights.
Chapter 9 Qualitative Analysis (Subject to Data Availability)
Segmentation Product Analysis 2019 -2031, will provide market size split by Product. This Information is provided at Global Level, Regional Level and Top Countries Level The report with the segmentation perspective mentioned under this chapters will be delivered to you On Demand. So please let us know if you would like to receive this additional data as well. No additional cost will be applicable for the same.
Chapter 10 Market Split by Product Analysis 2021 - 2033
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Chapter 11 Market Split by Application Analysis 2021 - 2033
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Chapter 12 Market Split by Assay Type Analysis 2021 - 2033
This chapter helps you understand the Key Takeaways and Analyst Point of View of the global G Protein Coupled Receptors GPCRs market
Chapter 13 Research Findings
Here the analyst will summarize the content of entire report and will share his view point on the current industry scenario and how the market is expected to perform in the near future. The points shared by the analyst are based on his/her detailed in-depth understanding of the market during the course of this report study. You will be provided exclusive rights to interact with the concerned analyst for unlimited time pre purchase as well as post purchase of the report.
Chapter 14 Research Methodology and Sources
Why Cell Lines have a significant impact on G Protein Coupled Receptors GPCRs market? |
What are the key factors affecting the Cell Lines and Detection Kits of G Protein Coupled Receptors GPCRs Market? |
What is the CAGR/Growth Rate of Cancer Research during the forecast period? |
By type, which segment accounted for largest share of the global G Protein Coupled Receptors GPCRs Market? |
Which region is expected to dominate the global G Protein Coupled Receptors GPCRs Market within the forecast period? |