G-protein Coupled Receptor Market Report 2025 (Global Edition)

Global G-protein Coupled Receptor Market Report 2025 Market Size Split by Product (Cell Lines, Detection Kits), by Application (Cardiovascular System, Central Nervous System (CNS), Oncology, Other App...

G-protein Coupled Receptor Market Report Description

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Impact of Tariff Trumph on Pharmaceuticals Industry

The reintroduction of tariffs under President Trump’s “Liberation Day Tariffs” in April 2025 has created significant disruption in global pharmaceutical trade. These tariffs, ranging from 10% to 46%, specifically target pharmaceutical products, APIs (active pharmaceutical ingredients), medical packaging, and machinery from key manufacturers in China and India. This has led to increased production costs, supply chain delays, and regulatory challenges for U.S.-based pharmaceutical companies.

The tariffs have particularly impacted generic drug manufacturers, who rely heavily on APIs from China and India. Biopharmaceuticals and vaccines are also feeling the pressure, with tariffs on critical materials like bioproduction media and cold-chain packaging raising costs by up to 25%. Similarly, contract manufacturing organizations (CMOs) are grappling with the need to identify new suppliers and adjust production plans to mitigate rising costs.

Foreign governments, including the European Union, have retaliated with tariffs on U.S. pharmaceutical exports, further complicating global trade. Clinical trials are also impacted, as tariffs on drugs and diagnostic kits delay trial timelines.

Market research is increasingly crucial for navigating these challenges. By providing real-time data on API pricing, supplier reliability, and tariff impact, pharmaceutical firms can make informed decisions on sourcing, compliance, and investment strategies. This data-driven approach helps mitigate risks, optimize supply chains, and identify alternative manufacturing hubs to offset tariff-related disruptions.

Overall, market research is essential for pharmaceutical companies to adapt to the new tariff landscape, enabling them to maintain competitive advantage and navigate global trade dynamics effectively.

Competitive Landscape: G-Protein Coupled Receptor Market

In order to meet the increasing demands of consumers the industry players are now investing and giving more attention to their research and development of G-Protein Coupled Receptor so that they sustain and survive in the competition. ensuring a competitive edge. Robust distribution networks and adherence to quality standards amplify market presence, fostering an environment where agility and innovation define industry leaders.

Recent Development 

In January 2025, Isogenica and Cube Biotech revealed a strategic partnership aimed at advancing therapeutics targeting G protein-coupled receptors (GPCRs). This collaboration merges Cube Biotech's cutting-edge technology for GPCR stabilization with Isogenica's unique synthetic VHH libraries, with the goal of facilitating the identification of antibodies against difficult GPCR targets.
https://isogenica.com/isogenica-ltd-and-cube-biotech-collaboration/
In September 2024, Superluminal Medicines, Inc., a biotechnology firm based in Boston, announced the successful completion of a USD 120 million Series A funding round. This funding round was led by RA Capital Management and included participation from Insight Partners, NVentures (the venture capital division of NVIDIA), Catalio Capital Management, Eli Lilly and Company, Gaingels, and Cooley LLP.
https://www.finsmes.com/2024/09/superluminal- 
In December 2024, AZo Life Science reported that researchers at Stanford University developed an innovative synthetic receptor capable of processing a broader range of inputs and producing a wider array of outputs. This invention, termed "Programmable Antigen-gated G protein-coupled Engineered Receptors" (PAGER), is founded on G protein-coupled receptors, a category of over 800 proteins present in the human body that activate G-proteins—molecular switches that regulate numerous vital cellular processes.
https://www.azolifesciences.com/news 
In April 2022, Ono Pharmaceutical Co., Ltd. entered into a new collaboration agreement with Domain Therapeutics and Université de Montréal to explore the discovery of novel small molecules aimed at targeting G protein-coupled receptors (GPCRs) within the context of metabolic diseases.
https://www.ono-pharma.com/en/news/20220419.html 
 

Top Companies Market Share in G-protein Coupled Receptor Industry: (In no particular order of Rank)

• Thermo Fisher Scientific Inc.
• Eurofins Scientific
• QIAGEN
• WuXi AppTec
• Promega Corporation
• Abcam plc
• Merck KGaA
• PerkinElmer Inc.
• Enzo Biochem Inc.
• BD
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*List of Second Tier Companies, List of Third Tier/ Start-up Companies (Inquire with sales executive) Request Any Company Profile for Preview Purpose OR Data Validation!

If any Company(ies) of your interest has/have not been disclosed in the above list then please let us know the same so that we will check the data availability in our database and provide you the confirmation or include it in the final deliverables.

Which Region will dominate the Market in 2025, and Which Region is Expanding at the Fastest CAGR?

North America stood as the largest region in the Global G-Protein Coupled Receptors Market during 2024. It is attributed to the high base of pharmaceuticals and biotech’s, extensive research facilities, and high spend on drug discovery.
The area has key stakeholders with active pursuits of GPCR-targeted pharmaceuticals, who use high-throughput screening equipment and novel assay systems. The growing incidence of chronic diseases like cancer, neurological disorders, and metabolic disorders has fuelled the need for GPCR-based therapeutics, resulting in increased use of detection kits, functional assays, and biosensor technologies.
The United States has been a driving force in the dominance of the market with its established regulatory structure, high investments made by institutions like the National Institutes of Health (NIH), and effective partnerships between universities and private institutions. As an example, The United States is commonly known to be the largest investor in the world for health sciences research. Out of the estimated $132 billion invested in total research.
 https://www.ncbi.nlm.nih.gov/books/NBK235736/ 

The Asia-Pacific G-Protein coupled receptors market will be forecast to grow with a CAGR of x% in the future years because more and more lifestyle diseases are growing at a large rate in India, China, and other countries in Asia Pacific, and to cure these ailments, there is a need to use the receptors. Additionally, the presence of some of the new entrants like Sosei Heptares, HD Biosciences Co., Ltd., and NB Health Laboratory, and expansion efforts the firms pursue in order to enhance their regional presence fuel regional expansion. For instance, in November 2024, Nxera Pharma and Antiverse agreed on a multi-target partnership to develop innovative GPCR-targeted antibody therapeutics based on generative AI. This partnership combines Antiverse's AI-based antibody design platform and Nxera's GPCR target selection capabilities to create revolutionary therapies for high unmet need diseases.
https://www.taylorwessing.com/en/insights-and-events/news/media-centre/press- 
 

The current report Scope analyzes G-protein Coupled Receptor Market on 5 major region Split (In case you wish to acquire a specific region edition (more granular data) or any country Edition data then please write us on info@cognitivemarketresearch.com

• North America (United States, Canada, Mexico)
• Europe (United Kingdom, France, Germany, Italy, Russia, Spain, Sweden, Denmark, Switzerland, Luxembourg, Rest of Europe)
• Asia Pacific (China, Japan, South Korea, India, Australia, Singapore, Taiwan, South East Asia, Rest of APAC)
• Latin America (Brazil, Argentina, Colombia, Peru, Chile, Rest of South America)
• Middle East (Saudi Arabia, Turkey, UAE, Egypt, Qatar, Rest of Middle East)
• Africa (Nigeria, South Africa, Rest of Africa)

The above graph is for illustrative purposes only.

G-protein Coupled Receptor Market Analysis

Based on products, the G-protein coupled receptors industry is segmented into cell lines and detection kits. The Detection kits segment led the market with the highest revenue share in 2024, Detection kits have become increasingly popular over the past few years, as they are simple to use, stable, and very sensitive products to assess activity via various pathways.
Additionally, novel detection approaches based on nonlabelled systems, including resonance wave-guide grating or impedance-based sensors, are expected to drive the growth of the segment. This is a consequence of their critical position in drug discovery, studies in signal transduction, and in applications in high-throughput screening. GPCRs are among the most thoroughly explored drug targets, and the intricacy of their signalling pathways calls for specific and effective detection means. Detection kits deliver standardized, trustworthy, and user-friendly formats to investigate the activity of GPCR that renders them necessary to research pharmaceutical as well as academic research labs. 
Detection kits are standardized, consistent, and user-friendly solutions for the analysis of GPCR activity and are invaluable to pharmaceutical and academic research facilities. The increasing need for GPCR-targeting drugs, especially in cancer, neurology, and inflammation studies, has hugely driven the use of these kits for screening and validation. The technology growth of high-throughput screening (HTS) platforms and the progression in biosensor technologies have also boosted the demand for GPCR detection kits. These kits enable real-time monitoring of GPCR interactions, which contribute to the discovery of new drug candidates with high specificity and efficacy. 
Furthermore, for instance, the rising availability of fluorescence-based and luminescence-based detection assays has improved the sensitivity and precision of GPCR research. The convenience, reproducibility, and versatility of detection kits in basic and translational research have made them the dominant product segment of the GPCR market.
https://pubmed.ncbi.nlm.nih.gov/31213021/#: 
Due to the presence of a wide variety of cell lines available for use in the assays. Cell lines are extensively involved in the cellular impedance assays used to identify GPCR targets and hence contributing to the estimated revenue share.
 

The above Chart is for representative purposes and does not depict actual sale statistics. Access/Request the quantitative data to understand the trends and dominating segment of G-protein Coupled Receptor Industry. Request a Free Sample PDF!

Application Segment Analysis of G-protein Coupled Receptor Market

This report analyzes revenue growth in the pharma and healthcare industry at global, regional, and national levels, highlighting trends and opportunities for each application. It explores how sectors like pharmaceuticals, therapy, and healthcare monitoring use innovations to address healthcare needs. Key factors include market size, revenue contributions, technological advancements (e.g., AI-driven diagnostics), and regulatory considerations. The report also covers the value chain, identifying key players and processes within the industry. For more information, please request a sample or contact our research team.

Some of the key Application of G-protein Coupled Receptor are:

• Cardiovascular System
• Central Nervous System (CNS)
• Oncology
• Other Applications

The above Graph is for representation purposes only. This chart does not depict actual Market share.

G-protein Coupled Receptor Assay Segment Analysis

• Calcium Level Detection Assays
• Radioligand Binding and GTPS Functional Assays
• cAMP Assays and cGMP Assays
• Arrestin Functional Assays
• Reporter Gene Assays
• Other Assay Types

Author's Detail

Manjiri Kanhere

Senior Research Associate at Cognitive Market Research

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Manjiri Kanhere is an experienced market researcher focused on the Pharma & Healthcare industry. With over 3+ years of experience, She has worked with major pharmaceutical companies and healthcare providers, helping them to understand market trends, identify new business opportunities, and develop effective sales & marketing strategies. Her expertise lies in the ability to analyze complex data sets and deliver insights that drive business decisions. At Cognitive Market Research, she handles the market research related to Pharma and healthcare industry.

Author's Conclusion