What is Metabolomics Services
Metabolomics aims to identify and measure small molecules, known as metabolites, in biological tissues and fluids. Metabolites encompass many chemical compounds, including but not limited to amino acids, organic acids, lipids, and environmental pollutants. These metabolites originate from various sources, such as the food we consume, the microbiota inhabiting our bodies, and metabolic pathways in our cells.
The field of metabolomics has experienced remarkable growth in recent years, driven by the development of advanced instrumentation and significant investments in laboratories with specialised expertise in this area of analytical chemistry.
Understanding Metabolomics and its Analytical Techniques
Metabolomics Service Market is crucial for investigating cellular metabolism and complementing other technologies, such as genomics and proteomics, by providing biochemical evidence. However, one of the most significant challenges in this field is the inability to detect and quantify the entire metabolome with a single analytical technique.
The two primary tools in metabolomics are mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. Mass spectrometry has exceptional sensitivity, making it ideal for detecting metabolites in very low abundance.
In contrast, NMR spectroscopy offers quantitative reproducibility and non-destructive analysis. Advanced NMR techniques provide powerful tools for the structural elucidation of unknown compounds and enable in vivo experiments. Both mass spectrometry and NMR are also capable of isotope tracing studies, which enable scientists to measure metabolite kinetics.
What a metabolomics service may offer?
Sample preparation: The service may assist in preparing samples for analysis, such as extraction, purification, and concentration of metabolites from biological matrices.
Analytical techniques: The service may offer a variety of analytical techniques to analyse metabolites, including mass spectrometry, nuclear magnetic resonance spectroscopy, gas chromatography, liquid chromatography, and capillary electrophoresis.
Data analysis: The service may provide expertise in data analysis and interpretation, including statistical analysis, metabolite identification, and pathway analysis.
The primary challenge in metabolomics is the inability to detect and quantify the entire metabolome with a single analytical technique. However, Metabolomics is a rapidly evolving field that has become a crucial tool for investigating cellular metabolism. The ability to identify and measure small molecules in biological tissues and fluids provides valuable insights into metabolic pathways and complements other technologies such as genomics and proteomics.
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