Digestive Enzymes Market Report 2025 (Global Edition)

Current scenario of the digestive enzymes market 

Key drivers of the Digestive enzymes market

• Increased Prevalence of digestive disorders driving market expansion

Over the forecast period, the worldwide enzymes market is expected to expand as the prevalence of digestive problems such as pancreatic insufficiency, lactose intolerance, food allergies, celiac disease, and microbial control rises. Pancreatic insufficiency, for example, occurs when the pancreas fails to produce enough digestive enzymes to aid in the digestion of food in the gut. As a result, this disease can be treated with additional digestive enzymes such as proteolytic, amylolytic, and lipolytic enzymes. 
Digestive disorders can have serious consequences, including reduced quality of life, premature death, and high costs for hospitalisation, medication, and surgery. Digestive diseases are the leading cause of ambulatory care visits in the US, accounting for an estimated 66.4 million visits per year.

Exogenous enzymes produced from yeast and fungus can be utilised to replace native lactase during lactose intolerance treatment. Furthermore, because the prevalence of most digestive ailments increases with age, the elderly are especially sensitive to these illnesses. As a result, the expanding geriatric population enhances the demand for effective drugs, propelling the digestive enzyme market ahead.

• Growing awareness of Gut Health leading to market expansion

The increased consumer awareness of gut health is projected to drive the digestive health products market. According to reports, intestinal inflammation and other irritable bowel illnesses such as Crohn's disease and ulcerative colitis have caused a number of deaths in the Western world in recent years. 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069527/

Constipation, changes in the digestive system, pharmacological side effects, inactivity, not drinking enough fluids, diverticular diseases, ulcers, NSAIDs, polyps, and GERD all contribute to the increased prevalence of these conditions as people age. Changes in food habits and greater intake of sodium-rich foods in developed and emerging nations are considered to be contributing factors to gastrointestinal problems. Digestive health products improve gut health, which helps to combat harmful germs and promote immunity. Probiotic yogurts are one of the few popular probiotic products with digestive health benefits. The growing awareness of the importance of good health has led to an increase in per capita spending on digestive health foods and beverages in major regional markets. The prevalence of digestive diseases in Japan, the United States, and Europe has boosted overall market demand. 

Consumers nowadays are willing to pay a bit more for improved health, which is projected to change the overall situation. Consumers' increased awareness of the benefits of probiotics in immunity, as well as their increasing disposable income, are projected to generate prospects for the worldwide probiotics market throughout time

Constraints for the global Digestive enzymes market

• Side Effects and Allergies Could Slow Market Growth 

 Some people may have negative effects like nausea, diarrhoea, and abdominal pains from taking digestive enzyme supplements. Some customers may have allergies to specific enzymes, limiting their ability to utilise these supplements. 
For example, While enzymes aid digestion, the inappropriate dosage might cause adverse effects and allergies, according to a report titled "Gastric Enzyme Supplementation Inhibits Food Allergy in a BALB/c Mouse Model".
Food allergies are becoming a major health concern, affecting up to 10% of the general population. Gastric acid suppressant medications have been associated to allergy development, however there are worries regarding their over-the-counter availability and long-term use. Gastric digesting can protect against food allergies by lowering allergen-specific antibody titters and decreasing allergic reactions. This study shows that gastric enzyme supplementation can improve stomach pH and protect against allergy symptoms. However, strict allergen avoidance remains the primary treatment option for food allergy patients, particularly younger ones.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996948/

These considerations may limit market growth of the global digestive enzyme market.

• Restrictions Against Animal Killing is hamper the market

Regulations against animal slaughter are a serious dampening factor on the expansion of the digestive enzymes market, especially for animal source-derived products. Historically, most digestive enzymes including pepsin, trypsin, and chymotrypsin are derived from the stomachs and pancreases of pigs and cattle. Nevertheless, growing international concern and activism regarding animal protection, combined with tighter regulations and moral requirements in a number of nations, are constraining the manufacture and marketing of animal-source enzymes.
Governments and regulatory agencies in Europe and other areas of Asia are enacting tougher regulations on the slaughter of animals and the use of animal by-products in foods, pharmaceuticals, and dietary supplements. The restrictions not only raise compliance expenses for manufacturers but also lower raw material availability, causing supply chain disruption.
Additionally, an increasingly larger group of consumers especially vegans, vegetarians, and consumers with religious or ethical dietary choices are consciously eschewing animal-derived ingredients. With this consumer trend, the market is being further pressured to source alternatives. Although plant-based and microbial enzymes are making inroads, there is much investment needed in research and development for the transition. Until scalable and affordable substitutes are more broadly mainstreamed, these limitations will continue to hold the digestive enzymes market back from expansion and dynamism.

Opportunities for the global Digestive enzymes market    

• Increased demand for plant-based and probiotic enzymes: 

The growing consumer desire for plant-based and natural alternatives, as well as the increased number of product launches, present considerable prospects for plant-derived digestive enzymes. Amylases are digestive enzymes derived from animals such as the pig, calf, or hog pancreas. However, because vegetarians do not choose these products, the product is likely to face difficulties. However, it is expected that concerns such as client sensitivity and allergies to these commodities may hamper expansion, thus Plant enzymes such as papain, bromelain, and aspergill pepsin are gaining popularity because of their effectiveness and safety. Growing study into probiotic bacteria as a source of digestive enzymes has increased the use of probiotic enzymes. These provide further digestive and immunological benefits. The creation of plant-based and probiotic enzyme supplements catering. For example, in June 2020, Enzymedica, a firm that manufactures high-quality natural digestive products, introduced its new Kiwi Regularity chewable, which has three times more enzyme activity for occasional constipation.
https://enzymedica.com/products/kiwi-regularity-chews

The development of plant-based and probiotic enzyme supplements in response to shifting customer preferences will broaden market opportunities.

• Higher Cases of Gastrointestinal Disorders is opportunities for market

The increasing incidence of gastrointestinal (GI) disorders provides an ideal opportunity for the expansion of the market for digestive enzymes. These include irritable bowel syndrome (IBS), lactose intolerance, indigestion, acid reflux, and pancreatic insufficiency, which are on the rise because of lifestyle changes, eating patterns, and stress levels. These disorders tend to result in poor digestion and nutrient absorption, generating increasing demand for digestive enzyme supplements that facilitate food breakdown and promote gut health.
For instance, the global incident cases of digestive diseases were 443.53 million (405.58–484.42) in 2019, increasing from 254.25 million (231.57 to 277.83) in 2023.
(Source- https://pmc.ncbi.nlm.nih.gov/)
With increasing awareness of the role of gut health in general well-being, more consumers are looking to enzyme-based products for relief and prevention. The demographic of an aging population, with a higher risk of digestive issues due to diminished natural production of enzymes, further fuels market growth. The increasing consumption of processed foods, often difficult to digest, has further created the demand for digestive support.
Medical practitioners are also prescribing enzyme supplements increasingly as a supportive, non-surgical treatment for GI conditions. Such medical recognition, along with increasing off-the-counter and prescription availability of enzyme preparations, is promoting consumer trust and adoption. As a whole, the spread of gastrointestinal diseases all over the world is not just propelling product innovation but also growing the customer base, thereby being one of the digestive enzymes market's primary growth drivers.

Impact of COVID-19 on the global Digestive enzymes market 

The new coronavirus has had a considerable influence on all industries, including food and beverage, automotive, and chemicals, among others. This epidemic has resulted in widespread industry shutdowns and supply chain disruptions, affecting the worldwide economy. As a result, these variables had an initial negative impact on the market. However, increased gastrointestinal problems among patients who suffered with COVID-19 positively impacted the market later on.
According to the article "Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome" released in December 2020, COVID-19 patients suffered gastrointestinal symptoms such as anorexia (17.9%), nausea (17.9%), and diarrhea (24.2%). It also stated that among patients who suffered badly from COVID-19, symptoms of gastrointestinal issues grew more apparent. Digestive enzymes aid in breaking down dietary molecules, making digestion easier. These proteins speed up the chemical reactions that convert nutrients into compounds that the digestive tract can absorb. Thus, digestive enzymes are a key component for treating gastrointestinal illnesses. As a result, such cases suggest that the market saw a beneficial impact during the pandemic's final stages.
https://pubmed.ncbi.nlm.nih.gov/32827705/#:~:text=Also%2C%20SARS%2DCoV%2D2,an%20increase%20in%20inflammatory%20cytokines.

The growing number of fitness centres and gyms, higher awareness of G1 health, and focus on preventive illness management are all contributing to the expansion of the digestive enzyme market. However, the market expansion is projected to be hindered by a lack of awareness about proper dose quantities and the availability of replacements for digestive enzyme supplements. Customised digestive enzymes provide a potential commercial opportunity.

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