What is Caspase 9?
Caspase-9 is an enzyme which is encoded by the CASP9 gene in humans. It is an initiator to the apoptotic pathway and its correct function is required for apoptosis, which ensures normal development of CNS. Besides, caspase-9 has multiple additional cellular functions, which include regulation of necroptosis, innate immune response, cellular differentiation, sensory neuron maturation, mitochondrial homeostasis, corticospinal circuit organization, among others. However, deficiency associated with caspase-9 largely affects the development of the brain.
Following are some of the driving factors that are increasing the market for Caspase 9:
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Surge in the prevalence of cancer
Cancer is the second leading cause of death globally, and is responsible for about 10 million deaths per year. It is estimated that about 1 in 6 deaths is due to cancer. Factors such as change in lifestyle, unhealthy consumption habits, physical inactivity and air pollution are primarily responsible for the surging prevalence of cancerous growth. Moreover, some chronic diseases are risk factors for cancer especially in low- and middle-income countries. Approximately 13% of cancers diagnosed in 2018 globally were attributed to carcinogenic infections, including Helicobacter pylori, human papillomavirus (HPV), hepatitis B virus, hepatitis C virus, and Epstein-Barr virus.
As caspase is a major mediator of apoptosis activated during cellular exposure to cytotoxic drugs, radiotherapy or immunotherapy. It is often used as a marker for efficacy of cancer therapy. Hence, increasing prevalence of cancer drives the growth of caspase-9 market.
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Benefits associated with apoptosis
Apoptosis has a vital role in biological processes, including aging, embryogenesis, and others. It is a genetically regulated form of cell death. It has been studied that about 10 billion cells die every day simply to keep balance with the numbers of new cells arising from the body's stem cell populations. The process is highly regulated by apoptosis. Functionality disorder in apoptosis can cause a wide array of diseases. For instance, increased apoptosis can cause AIDS, or neurodegenerative diseases, while decreased apoptosis is a feature of many malignancies, and autoimmune disorders. Caspase-9 is very important in apoptosis and cytokine signaling.
Conclusion:
Abnormal caspase-9 levels in the body impact normal functioning of the body. It can lead to future work in inhibition through targeted therapy, specifically with diseases associated with the brain. Introduction of this enzyme in a treatment form has a wide array of medical benefits. Its main function is to eliminate damaged cells. After activation, it cleaves proteins necessary for cell survival, promoting apoptosis. Caspases 3 are therefore usually regarded as being helpful in the treatment of cancer.
Author's Detail:
Raziya Kotadiya / LinkedIn
Research Analyst at Cognitive Market Research
With a demonstrated history of working in the market research covering qualitative and quantitative research. Skilled in Strategic Forecasting, Market Research, Competitive Intelligence, Business Development, Trend and Opportunity Analysis and Data Visualization.
Author's Detail:
Raziya Kotadiya /
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